Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

A laser (purple) is powerfully amplified by highly polished mirrors and focused on the electron beam (blue) to shift its phase and increase the cryo-EM microscope’s contrast, allowing biologists to ...

Every year, thousands of patients with early-stage breast cancer undergo surgery that removes the tumor along with a rim of ...

Physicists have demonstrated a laser-based method that enables a cryogenic electron microscope to image small protein structures with greater detail than previously possible. The laser phase plate ...

Key points of this article In 1958, Nippon Kogaku K.K. released the "Nikon Portable Microscope Model H," which originated ...

A microscope born in post-war JapanThis time, I am introducing an old Olympus biological microscope, the UCE model ...

The invention that first enabled researchers to see clear images of living cells was the phase-contrast microscope, which won its inventor, Frits Zernike, a Nobel Prize in 1932. Prior to Zernike's ...

Quantitative phase imaging is a powerful, non-invasive and quantitative microscopy technique that allows multi-scale imaging of cellular systems, explain Mustafa Mir and Gabriel Popescu Imaging by ...