Vanderbilt University has synthesized muscarinic M4 receptor positive allosteric modulators (PAMs) reported to be useful for the treatment of Alzheimer’s disease, pain, schizophrenia and sleep ...

Muscarinic acetylcholine receptors (mAChRs) constitute a family of five G protein-coupled receptors (M1–M5) that mediate the diverse actions of acetylcholine in the central nervous system.

Myopia, a leading cause of visual impairment globally, can progress to serious complications like retinal and choroidal degeneration. While atropine is commonly used to manage childhood myopia, its ...